1 Nm 23 - H 1 regulates contact inhibition of locomotion which is affected by ephrin - B 1
نویسندگان
چکیده
Masamitsu Tanaka*, Sei Kuriyama and Namiko Aiba From the Department of Molecular Medicine and Biochemistry, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan Running Title: Nm23H1 regulates contact inhibition of locomotion *Address correspondence to: Masamitsu Tanaka, Tel. +81-018-884-6077; Fax. +81-018-884-6078; E-mail address: [email protected] Abbreviations footnote: GST, glutathione S-transferase; GEF, guanine nucleotide exchange factor; aa, amino acid; i.c., intracranially; RNAi, RNA interference
منابع مشابه
Nm23-H1 regulates contact inhibition of locomotion, which is affected by ephrin-B1.
Contact inhibition of locomotion (CIL) is the process by which cells stop the continual migration in the same direction after collision with another cell. Highly invasive malignant cells exhibit diminished CIL when they contact stromal cells, which allows invasion of the tissue by tumors. We show that Nm23-H1 is essential for the suppression of Rac1 through inactivation of Tiam1 at the sites of...
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